The importance of patient-matched tumor-normal sequencing
Learn about our unique approach and how it applies to TMB and personalized therapy selection.
For providers
Resources
Resources designed to support your practice
From videos and case studies to patient guides and more, find the tools to help you use the OncoExTra® test most effectively.
Oncotarget
The impact of DNA and RNA testing on patient care
Analyzed data from over 10,000 solid tumor samples from patients with advanced cancer found that more than 90 percent contained genomic changes that could guide treatment, as published by Oncotarget.
Breast Cancer Research
ESR1 alterations in patients with breast and gynecologic cancers
A study of 2,574 breast cancer and 1,110 gynecologic cancer samples that underwent whole-exome and whole-transcriptome profiling was conducted to assess the distribution of ESR1 alterations.*
General Resources
OncoExTra test overview
PDF
A comprehensive overview highlighting how the OncoExTra test can help identify alterations in patients diagnosed with advanced cancers.
Patient brochure
PDF
Everything your patients need to know about the OncoExTra test and the benefits of biomarker testing.
Pathologist guide
PDF
Discover how the OncoExTra test gives pathologists the power to enable more personalized care through optimized testing and tissue processing.
Actionable genomic alterations
PDF
See how healthcare providers can better identify and manage cancer patients with actionable genomic alterations, leading to improved treatment outcomes.
Articles and case studies
The importance of ultra-comprehensive genomic profiling
PDF
Chief Medical Officer of Precision Oncology at Exact Sciences, Rick Baehner, writes about the importance of ultra-comprehensive genomic profiling in advanced cancer therapy selection.
Patient-matched tumor normal sequencing: What it is and why it matters
PDF
Dive into patient-matched tumor-normal (PMTN) sequencing, why it’s a gold standard method for calculating tumor mutational burden, and why it matters for oncologists as written by Drs. Amin Mazloom and Janine LoBello.
OncoExTra and advanced lung cancer overview
PDF
Understand how the all-encompassing genomic profiling of the OncoExTra test helps to guide patient treatment.
Next-generation RNA and DNA sequencing
A series of seven cases showcasing the value of comprehensive genomic sequencing to maximize the identification of clinically actionable alternations in advanced cancer patients.
Order forms and billing resources
Provider Hub ordering guide
Read the step-by-step guide to placing and managing test orders on the Exact Sciences Provider Hub.
Specimen request form
Two specimen samples are required as part of each OncoExTra test order. You can request these by calling Customer Service at +1 866-662-6897 or by submitting a request form.
Specimen collection and shipping guidelines
PDF
Download our specimen requirements and shipping guidelines to ensure the integrity and accuracy of the OncoExTra test.
New York state test requisition form
PDF
Test requisition form and statement of medical necessity specific for orders placed in New York.
Billing and coverage card
PDF
Help your patients understand what’s covered and how to navigate the billing process when they decide to take the OncoExTra test.
Sample reports
Lung sample report
Each OncoExTra lung report will highlight the most clinically relevant information, to support prompt, point-of-care discussions between providers and their patients.
Breast sample report
PDF
Videos
Frequently asked questions
What is patient-matched tumor-normal sequencing and why is it important?
Every person has unique genetic variants in DNA, but some of them are benign. When sequencing the DNA, the OncoExTra test uses patient-matched tumor-normal sequencing to rule out the benign variants and identify those that are most likely to respond to therapy. Using patient-matched tumor-normal sequencing also provides a more accurate calculation of tumor mutational burden. It’s considered a gold standard for germline subtraction and is not offered by all comprehensive genomic tests.1-3
I am ordering the OncoExTra test for the first time. How do I get started?
To order the OncoExTra test, begin by calling Customer Service at +1 866-662-6897 to request specimen kits or by completing the specimen kit request form . Submit a test order directly through our Exact Sciences Provider Hub or by downloading the
What are the requirements for shipping?
Exact Sciences will supply OncoExTra specimen kits for shipping. Please ensure all primary specimen containers are labeled with two unique patient identifiers and the collection date. Ship samples in the supplied specimen kits according to our shipping guidelines .
How long will it take to get patient results back?
Exact Sciences strives to provide accurate and timely patient results. You can expect to receive results within 14 days from the date we receive both the tumor and blood samples in our laboratory.2
How will I receive the patient report?
You can easily access patient results through the Exact Sciences Provider Hub or receive the report by fax. When new patient results are ready, you will be notified by email. Reports may be viewed online, printed, or downloaded as PDFs.
Is my patient eligible for coverage assistance?
Exact Sciences believes that everyone should have access to the information they need to make decisions about their cancer treatment. Learn more about how our team can assist with prior authorizations, billing insurance, appealing denied claims, and providing flexible payment options on our insurance coverage and billing page.
What is the average out-of-pocket cost to patients?
96% of patients who receive the OncoExTra test have $0 in out-of-pocket costs.4 97% of patients who have a financial responsibility pay <$100.4 Between Medicare Fee for Service and many commercial insurers, the OncoExTra test has been covered for over 150 million people.4,5 Out-of-pocket (OOP) costs for the test, if any, are determined by the patient's insurance company. Patients with OOP costs may contact us to discuss options.6
Have questions?
Call us at 1 866-662-6897 .