Understanding Your Oncodetect™ Molecular Residual Disease Test Results

For patients

Test results

We make it easy to understand your Oncodetect^® Molecular Residual Disease (MRD) test results. You’ll see whether or not DNA fragments from your tumor have been detected in your blood, the amount detected (if any), and a historical chart of your past results. Your doctor will review the results with you and help decide on next steps.

A smiling man sitting on a couch with his computer.

The Oncodetect MRD test report provides clear and simple results, showing whether any circulating tumor DNA (ctDNA) was detected in your blood and tracking your ctDNA levels over time. The report can help you and your doctor evaluate your risk of cancer recurrence and monitor your response to treatment.

Detected or not detected

The report begins with a positive or negative, showing whether any ctDNA from your tumor has been detected in your blood. A positive result means ctDNA was detected. A negative result means no ctDNA was detected.

The amount of ctDNA detected, 5.20 MTM/ml.

Amount detected

If ctDNA is detected,* the amount of ctDNA will be shown as “mean tumor molecules per milliliter of plasma [MTM/mL].”

Trends over time

Tracking your ctDNA levels over time — pre-surgery, post-surgery, during, and after adjuvant therapy — can help you and your doctor make more informed treatment decisions.

Your personalized Oncodetect MRD test report will show the amount of ctDNA found in your bloodstream. If you are monitoring MRD over time, you’ll see a historical graph of your levels, suggesting evidence of cancer recurrence, progression, or regression.

A “Negative – ctDNA not detected” result means the Oncodetect MRD test has found no identifiable evidence of MRD. It could also signify a lower risk of recurrence or progression.3,†

A “Positive – ctDNA detected” result means you are at a higher risk of recurrence or progression.3,† Knowing your results, and the trend of ctDNA levels over time, can help you and your doctor decide on the best treatment plan.

After your doctor orders the Oncodetect MRD test, you’ll receive an email or text to sign up for your Exact Sciences patient account.† Once your account is created, you can track your test order, access your test results as soon as they’re available, get support from customer care, and more.

Someone on their laptop reviewing results.

You’re not alone. Specialists from Exact Sciences can provide support to help you navigate the insurance and billing process, as well as assist with prior authorizations, billing insurance, appealing denied claims, and providing flexible payment options when necessary.

Call +1 888-662-6897

Call us at +1 888-662-6897.

References and footnotes

Quantitative results are only reported if above the analytically validated limit of detection.
All Oncodetect MRD test results should be discussed with your healthcare provider. A negative result does not definitively rule out the presence of residual disease in the body. A positive test result means the test detected ctDNA, but does not definitively signify cancer recurrence or progression.
If your health care provider did not include your mobile phone number or email address when submitting the lab order, you will not receive an SMS message or email from Exact Sciences.

Abbott Cancer Diagnostics. Oncodetect V2.0 Analytical Validation. Internal presentation. Sept 3, 2026.
Centers for Medicare & Medicaid Services, Medicare Coverage Database. LCD—MolDX: Minimal Residual Disease Testing for Cancer. Accessed January 21, 2025. https://www.cms.gov/
Diergaarde B, Young G, Hall DW, Mazloom A, Costa G, Subramaniam S, Palomares M, Garces J, Baehner FL, Schoen RE; and other members of the Exact Sciences MRD Group. Circulating tumor DNA as a marker of recurrence risk in Stage III colorectal cancer: The α‐CORRECT study. Journal of Surgical Oncology.

The Oncodetect^® test was developed, and its performance characteristics determined by Genomic Health, Inc. Performance characteristics may not apply in tumor types not included in this test’s clinical validation. The test has not been cleared or approved by the US Food and Drug Administration. The test is performed at Genomic Health Inc. The Genomic Health Inc. lab performing this test is certified under CLIA regulations and qualified to perform high-complexity clinical laboratory testing.

How to read your test results

Explore your Oncodetect MRD test report

Detected or not detected

Amount detected

Trends over time

The Oncodetect MRD test can detect cancerous DNA even when it makes up less than one-millionth of the DNA in your blood.1

Breaking down the results

Low likelihood of recurrence

Risk of recurrence

It’s easy to view your test results

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References and footnotes